From: lamontg@cs.washington.edu
Newsgroups: alt.drugs
Subject: Re: methcasidone recipe
Message-ID: <25bp20$ktb@news.u.washington.edu>
Date: 24 Aug 93 00:57:36 GMT
jcaffey@lonestar.utsa.edu (Jeffrey S. Caffey ) writes:
correct.
>and it contains a strong base (lye, something like NaOH), battery acid,
and
>ephinedrine (from diet pills and nasal sprays, etc.).
it does not
"contain" those anymore than water "contains" hydrogen.
ephedrine is the
precursor. NaOH and H2SO4 are used in the synthesis
to acidify or basify the solution that
you’re working with at various
stages — it doesn’t contain NaOH or H2SO4 *PERIOD*. it may
"contain"
HCl as a hydrochloride salt, but so does the ephedrine and
pseudoephedrine
that you buy over the counter.
>Of course, I could be
>wrong. That’s what I learned from watching, believe it or not, The Today Show
>with
Katie Curic. Sounds like you would have to be high to want to get high
>on that shit!
what you’ve mentioned here has no relevancy to wether or not you’d want to
get high on
it.
>So how DO you make it?!! 
From: an26424@anon.penet.fi
(Badsector)
Date: Thu, 22 Jul 1993 15:20:21 GMT
Newsgroups: alt.drugs
Subject:
Methcathinone Info
Methcathinone ("Cat") / Ephedrone ("Jeff").
Initially reported as a street drug in
the former USSR as ephedrone
[1]. Reports of the use of "Jeff" leading to
"numerous" overdose deaths
were, it seems, covered up by the former Russian
authorities. It has been
banned in the USA after several labs were seized in Michigan. It was
sold
as "Cat", presumably named after the African shrub Khat (catha
edulis),
which contains cathinone [2]. Methcathinone is related to
cathinone as methamphetamine is
related to amphetamine, i.e. by
N-methyl substitution.
Reliable reports of
effects in humans are not known to me. A recent short
letter [4] in the Journal of the
American Medical Association seems to me to
simply to repeat assertions made in the American
popular press. In the letter,
it is said that users describe "Cat" as better than
cocaine and meth.
"Typical" doses are described as 0.5-1g and the effects described
as lasting
six days.
This seems to me to be unlikely. What has been reported may
well be
equivalent to high dose, methamphetamine abuse on the "speed freak"
pattern
and is probably *not* typical.
Animal studies [2] suggest methcathinone
has ED50 of 1.9uM/kg
(0.39mg/kg) , when compared to cocaine’s 7.6uM/kg (2.6 mg/kg). This would
make it *more* potent than cocaine by six times in the rat and
suggests the human
figure of ten times cocaine potency in the human reported
on USENET as been given on Belgium
television is not unrealistic. Indeed, this
would put it in the same range as methamphetamine,
which it may well closely
resemble.
Personal communication suggests it may well
be simply equivalent to
methamphetamine. The bottom line may well be that most CNS
stimulants
are the same, whether they be cocaine, methamphetamine, amphetamine,
4-methylaminorex or methcathinone. Differing the route of administration is
likely to have
more effect. Smoking or injecting such drugs leads to rapid
build-up of the drug in the blood
stream and an intense "rush". This route
is more dangerous from a toxicologic point
of view and likely to lead to
compulsive use. Occasional oral use in social situations is
likely
to be the least harmful. Some people may find CNS stimulants psychologically
addictive.
Synthesis [1]
A 2000-mL Erlenmeyer flask, equipped with a
magnetic stirring bar, was
charged with methylene chloride (200 mL), acetic acid (10 mL) water
(100 mL),
potassium permanganate (2g) and ephedrine hydrochloride (2g). The solution was
stirred at room temperature for 30 min. This was followed by the
addition of sufficient sodium
hydrogen sulfite to reduce the
precipitated manganese dioxide. The aqueous phase was made
basic
with 5N sodium hydroxide (NaOH) and the methylene chloride was
separated. The
organic layer was extracted with 0.5N sulfuric acid
(H2SO4). Isolation of the acid layer
followed by basification with
sodium bicarbonate and extraction with methylene chloride (50
mL,
three times), removed the product into the organic phase. The solvent
was
concentrated by rotary evaporation, followed by column
chromatography through neutral alumina
with methylene chloride.
Solvent removal through rotary evaporation produced a colorless
liquid which was disolved in hexane. Gaseous hydrochloric acid was
bubbled into the hexane to
precipitate the amine hydrochloride to
produce a 1-g (50%) yield of
2-methylamino-1-phenylpropan-1-one
hydrochloride.
Ephedrone, like
methamphetamine, processes one asymmetric center.
Depending upon the synthetic precursor,
l-ephedrine (1R,2S) or
d-pseudoephedrine (1S,2R), the product expected would be d-ephedrone
heat of the reaction or
harsh extraction conditions the enolizable
ketone will result in a racemic d,l-ephedrone.
Synthesis [3]
A solution composed of 0.99g of sodium dichromate and 133g
of
concentrated sulfuric acid dissolved in 4.46 cc of water is added
slowly with
stirring to 1.65g of l-ephedrine dissolved in 4.7 cc of
water and 0.55 cc of concentrated
sulfuric acid at room temperature.
The mixture is stirred at room temperature for an
additional 4 to 6
hours and then made alkaline with sodium hydroxide soloution. the
aqueous mixture is extracted with two volumes of chloroform and then
with two volumes of
ether. The organic extracts containing the free
base of 1-a-methylaminoprophenone are
combined, treated with an
excess of dry hydrogen chloride and the solvents evaporated. The
petroleum ether,
collected and purified by dissolving in ethanol and
reprecipitating with ether. m.p. 182-184 o
C.
(1) Zingel, K.Y., Dovensky, W., Crossman, A. and Allen, A.,
"Ephedrone:
2-Methylamino-1-Phenylpropane-1-One (Jeff)," Journal of
Forensic Sciences, v. 36, No.3,
May 1991, pp.915-920
(2) Young, R. and R.A. Glennon. "Cocaine-Stimulus
Generalization to
Two New Designer Drugs: Methcathinone and 4-Methylaminorex"
Pharmacol. Biochem. Behav. 45(1) 229-231, 1993
(3) Glennon, R.A., Yousif, M., Kalix, P.
"Methcathinone: A new and
potent amphetamine-like agent." Pharmacol. Biochem.
Behav.
26:547-5451, 1987.
(3) British Patent, 768,772 (1954).
(4)
Goldstone, M.S., "Cat - Methcathinone - A New Drug of Abuse" Journal
of the American
Medical Association v269 no 19 p2508 (letter) 1993
————————————————————————-
To find out more
about the anon service, send mail to help@anon.penet.fi.
Due to the double-blind, any mail
replies to this message will be anonymized,
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Please report any problems, inappropriate use etc. to
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>Of course, I guess the college guy figured out that everything
needed was
>right under the counter. Now what’s the government going to do? Outlaw
>batteries and drain cleaners? I wouldn’t put it past them.
i really doubt it.
—
Lamont Granquist drugz: ftp.u.washington.edu:/pub/user-supported/alt.drugs
lamontg@cs.washington.edu personal: !finger lamontg@cs.washington.edu | more
"Conservative: n. One who admires radicals centuries after they’re dead."
=============================================================================
From:
cooper@hacktic.nl (cooper)
Newsgroups: alt.drugs
Subject: Re: Ephedrine Derivatives
Message-ID: <2991olINNo8m@xs4all.hacktic.nl>
dyer@spdcc.com (Steve Dyer) writes:
>In article
<1993Oct9.200043.25880@news.yale.edu> potter@minerva.cis.yale.edu (Philip G. Potter)
writes:
> >It is supposedly easy to make, using Ephedrine Hydrochloride (over the
> >counter stimulant) and other household chemicals. Do anyone have any
>
>information on this.
>You’ve got to be kidding. You’d need a chemistry lab.
Well, a chemistry lab and some knowledge _might_ help, but hey, if you wanna
give it
a shot, Here’s howto: (well, at the end of this post, that is!
Oh this is the end huh?? Ok,
here goes:
I’ve never tried this synthesis, and I can’t be sure baout anything.
However,
if your kitchen does not explode, and you have a good time anyway, lemme know.
Methcathinone
Preparing the ephedrine/pseudoephedrine solution:
Method A:
Add enough water to completely dissolve pure ephedrine or
pseudoephedrine.
Method B:
Wash sudaphed tablets in cold water until most (it’s impossible
to get all of it) of the red coating is gone. Put the tablets
in hot water, heat them to
boiling, and stir until the tablets
have completely dissolved. Filter off the liquid.
The amount of water the (pseudo-)ephedrine [I'll call it
ephedrine from now on for
simplicity] is dissolved in is not too
important - it should be as little as possible, but at
least as
much as the amount of sulfuric acid that is added later (to
insure to that the
potassium dichromate dissolves).
To this aqueous mixture add 0.62 grams of potassium
dichromate
for every gram of ephedrine in the solution. If you used
sudaphed tablets,
figure by the theoretical amount in
solution (number of tablets X content of each tablet).
Slowly
add 3ml Sulfuric for each gram ephedrine, stirring as you add
it.
Let react for 30-60 minutes. The color should go from a bright
red/orange to a dark color (a
mixture of green and orange from
the two ionization states of the chromium).
Basify the
solution with concentrated sodium hydroxide solution
until you see the solution become a
bright green (green with a
white precipitate - the methcathinone). This happens above pH
8. Try not to add too much hydroxide (if you do the solution
becomes black and there is
probably some decomposition of the
methcathinone).
Extract 3-4 times with naptha
(add the naptha, shake it up,
pour off as much naptha as you can - but DON’T get ANY
reaction
mixture in the extracts!). Use as much naptha as would equal
about 50-100
percent of the reaction mixture.
Quickly add the extracts to 25ml of
hydrochloric acid, diluted
1 part 36% HCl to 4-5 parts water. Shake the mixture, extract
off the aqueous (lower) portion. This is an acid solution of
the methcathinone. [you may want
to extract a second time with
HCl to get a slightly higher yield, a 3rd time adds nothing.]
under a vacuum) until it becomes
thick. Add acetone and stir
it a little. if the mixture doesn’t become white (crystalline)
evaporating and adding acetone until
it does. Be careful not
to burn the thick mixture (adding acetone helps keep the
temperature down).
After getting crystals/precipitate, cover the mixture tightly
and put in a freezer for 15 minutes. Remove from the freezer,
filter the crystals off and wash
with a small amount of cold
acetone.
[If the crystals are less than white, you may want
to purify
them by boiling and stirring them in acetone again, cooling
the mixture and
refiltering as described above.]
The white crystals/powder is methcathinone HCL. I
wouldn’t
take more than 20mg for a first dose, and I wouldn’t take it if
I had a history
of heart disease or stroke in the family, or if
I had high blood pressure. Really, really
habit forming. Very,
very pleasurable. BE CAREFUL. Don’t introduce this stuff to
kids or
sell it or I will personally hunt you down.
NOTES:
This synthesis is very
forgiving. Substitutions of potassium
hydroxide for sodium hydroxide, sodium dichromate for
potassium
dichromate and similar subsitution will not have an impact. I
wouldn’t
substitute anything for the sulfuric acid, however.
HCl is used to make the drug salt because
it is so easy to
evaporate the excess off. Any method of making drug salts you
are
familiar with should be satisfactory.
Ether works a little better than naptha, but it’s
more
dangerous. I stay away from it.
——————————————————————-
–Cooper
Message-ID: <051314Z09071994@anon.penet.fi>
Newsgroups: alt.drugs
From:
an42976@anon.penet.fi
Date: Sat, 9 Jul 1994 05:11:24 UTC
Subject: Tips for CAT
synthesis
Through experience I have compiled the following tips for ppl wanting
to do the CAT synthesis. It isn’t hard, but the posted synthesis cannot
lead to good results
becuase of certain ommisions. I don’t know if these
were omitted deliberately as to stop
non-chemists from completing it or
whether the author of the original article just forgot. In
any case, here
are some things you should be aware of.
1) When dissolving the
ephedrine don’t use ‘as little amount of water as
possible’ as the instructions say. This will
lead to a very thick reaction
mixture. When extracting with naphta this thickness will prevent
separation
of layers. The naphta will stay in suspension and the naphta that does
separate will not contain high amounts of CAT. This leads to unacceptably
low yields. Use
about 10 ml. of water per gram of dissolved ephedrine. Do
not use tap-water, get
de-mineralised water. Trace amounts of minerals will
inhibit the reaction.
2) Add the
sulphuric acid *very slowly*. If you don’t, local concentrations
will get too high, causing
the ephedrine to break down. Stir well while
adding the H2SO4.
3) This is the most
important omission: The whole reaction mixture has to
be cooled while basifying it with Sodium
hydroxyde. The heat developed
during this stage will cause practicaly all the CAT to break
down if you
don’t. The best way to cool it is as follows: Place the reaction mixture
in
an ice-bath 10 minutes before adding the NaOH. Then, just before adding
the NaOH, chuck a
handfull of salt over the ice (NOT in the reaction
mixture!) This will cause the temperature
to drop another couple of
degrees, ensuring a good cooling.
4) Use a magnetic stirring
device troughout the whole procedure.
5) When extracting the CAT from the naphta with the HCl
use a 20%
solution in stead of the mentioned 10% (approx.)
6) When evaporating the
excess amounts of water (preferably under vacuum)
do not let the temperature exceed 70 degrees
C. (approx 150 F.) Again, the
high temperature would cause the CAT to disintegrate. 
If you follow these additional comments, you should be able to have success!
The
anonymous chemist.
————————————————————————-
To find out more
about the anon service, send mail to help@anon.penet.fi.
Due to the double-blind, any mail
replies to this message will be anonymized,
and an anonymous id will be allocated
automatically. You have been warned.
Please report any problems, inappropriate use etc. to
admin@anon.penet.fi.
=============================================================================
_____________________________________________________________________________
MAKING CAT
(METHCATHINONE)
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
For a more
complete description of how cat is made read "Secrets of Meth-
amphetamine
Manufacture" (Third Edition), available from Loompanics Unlimited,
PO Box 1197 Port
Townsend, WA 98368 USA. Eye protection is needed and this is
done in a well-ventilated area.
AT LEAST a year of college chemistry lab
experience is needed to realize the dangers involved
here. This article is for
information purposes only.
Cat (METHCATHINONE) is made
by oxidizing EPHEDRINE, while METHAMPHETAMINE is
made by reducing EPHEDRINE. Cat is best made
by using CHROME in the +6
oxidation state as the oxidizer. Any of the common hexavalent
CHROME salts
can be used as the oxidizer in this reaction. Some of these are CHROME
TRIOXIDE (CrO3), SODIUM or POTASSIUM CHROMATE (Na2CrO4), and SODIUM or
POTASSIUM DICHROMATE
(Na2Cr2O7). All of these chemicals are very common.
CHROME TRIOXIDE is used in chrome
plating.
First the chemist dissolves EPHEDRINE pills containing a total of 25 grams
pills usually
contain 25mg each of EPHEDRINE so 1000 pills would be needed.
Grinding them up isn’t
necessary. Let them sit overnight or shake the
solution hard for a while. When they’re
dissolved bring the solution to a
gentle boil while constantly stirring so none of it burns.
As soon as it
starts boiling remove it from the heat and pour through 3 coffee filters
layered together to filter out the unwanted filler crap. Usually it is
necessary to hold the
filters like a bag with the liquid that didn’t go
through and gently squeeze to get the
liquid to go through. The result is an
almost totally clear liquid which is the EPHEDRINE
extract in water. Throw the
mush left in the filter away.
The EPHEDRINE extract
is poured into any convenient glass container. Next,
75 grams of any of the above mentioned
CHROMIUM compounds is added. They
dissolve easily to form a reddish or orange colored
solution. Finally,
CONCENTRATED SULFURIC ACID (it usually comes as 96-98%) is carefully
added.
If CrO3 is being used, 21 ml is enough. If one of the CHROMATES is being used,
42
ml is needed. These chemicals are thoroughly mixed together and allowed
to sit for several
hours with occasional stirring.
After several hours LYE solution (1 part water, 1 part
LYE) is very slowly
and carefully added dropwise with strong stirring until the solution is
strongly basic (pH 11 or more). This strong stirring is to make sure the cat
is
converted to the free base.
Next, TOLUENE is used to extract the cat. Usually this is
done with a sep
funnel (separatory funnel, which is a flask with a funnel-shaped bottom and
liquids by
opening the valve on the bottom and letting the bottom-most layer
of liquid drain out.) but a
regular glass bottle should be fine but using a
plastic cap wouldn’t be good. For safety, the
bottle would need to be "burped"
often anyway to make sure no gasses build up in it.
A large eyedropper-type
tool could be used to efficiently remove the cat layer. A couple
hundred ml’s
of TOLUENE is added and the container is strongly shaken to make sure the all
milk (fine
suspended globules of TOLUENE within the water layer). Shake really
hard, then allow it to
separate. Insufficent shaking will result in poor yield
with some undissolved cat base
remaining in the spent sludge layer. The
TOLUENE layer should be clear to pale yellow in
color. The water layer should
be orange mixed with green. The green may settle out as a heavy
sludge. The
water layer is thrown away and the TOLUENE layer is washed once with water and
and
the mixture shaken again and separated. The cat free base stays in the
TOLUENE layer because
it doesn’t dissolve in water. Any remaining
water-soluble impurities are dissolved into the
water layer and not the
TOLUENE layer and thus they’re "washed" out.)
The cat free base now must be converted to cat salt (METHCATHINONE HCL).
Here are 2 methods
for doing this.
METHOD 1
~~~~~~~~
Dry HCL gas is made and bubbled through the
TOLUENE solution to turn the cat
free base into cat salt (METHCATHINONE HCL). A bottle is
selected for holding
the gas-producing mixture and a 1-hole stopper will be put in the top of
the
bottle. One end of a J-shaped glass tube (about 1/4 inch diameter) is pushed
into
the stopper. This glass tube will reach from the top of the gas-producing
bottle down into the
bottle holding the TOLUENE-cat mixture. It should reach
the bottom of the mixture. Usually a
sep funnel is used to add SULFURIC ACID
to the gas-producing mixture through a second hole in
the stopper to keep gas
flowing. If one doesn’t have access to a sep funnel it should be
possible to
take the stopper out of the gas-producing bottle just long enough to add a
little SULFURIC ACID when it’s needed to keep gas flowing. Place 200 grams of
TABLE SALT into
the gas-producing bottle. 35% CONCENTRATED HYDROCHLORIC ACID
(reagent grade) is added and they
are mixed into a paste. The surface of the
paste should be rough with lots of holes poked into
it for good gas
production. About 1 ml of CONCENTRATED (96-98%) SULFURIC ACID is added to
the
paste. This dehydrates the HYDROCHLORIC ACID and produces HYDROGEN CHLORIDE
GAS (**
DO NOT BREATHE THIS GAS! **). This gas goes out of the gas-producing
bottle through the glass
tube and bubbles through the TOLUENE-cat solution
turning cat free base into cat salt. The
cat salt should appear as crystals
and after a while the solution should be thick with them.
The crystals are
recovered by pouring through a filter. The crystals are then dried by
evaporating the TOLUENE with gentle heat or under a vacuum. Voila. Pure
METHCATHINONE-HCL.
METHOD 2
~~~~~~~~
That was the "ideal" method. The practical method
is to dump the base/solvent
solution into a container, add an amount of DILUTE HCl, shake,
shake, shake,
measure pH, if it is greater than 7 (pH above 7 is basic), add more acid,
staying well
below 7 (pH below 7 is acidic), then remove the solvent layer and
keep for reuse. Add BAKING
SODA to the water layer a little at a time until it
stops bubbling when more is added. Check
the pH, make sure it is 7 (neutral)
or higher. The water is now evaporated away on
non-plastic plates or pans and
the dried METHCATHINONE HCL can be scraped off with a razor
blade. The
METHCATHINONE HCl has a trace of SODIUM CHLORIDE (TABLE SALT) and an even
smaller trace of SODIUM BICARBONATE (BAKING SODA). The BAKING SODA combines
with the excess
HCl to become TABLE SALT. This practical method avoids the
mess of producing HCl gas. HCl is
a white gas that burns your eyes and nose
really badly should you breathe it. It converts
upon contact with water into
HYDROCHLORIC ACID, so if you don’t want HYDROCHLORIC ACID in
your eyes, nose,
lungs, don’t breathe it!
Small amounts of TABLE SALT and
BAKING SODA in the cat will go unnoticed. The
ideal method can be used if a source of
compressed HCl GAS is found. It is
sold in lab cylinders by chem supply houses and is not
watched by the DEA.
Just stick on a regulator, affix the rubber hose with a glass extension
for
submersion in the solvent, and open the valve to expel the gas through the
solvent
to produce PURE cat HCl.
_____________________________________________________________________________
SUMMARY
~~~~~~~
Ephedrine is oxidized to produce methcathinone. The methcathinone is then
converted to the free base for separation from the rest of the unwanted crap
mixed with it.
The free base dissolves in toluene and not in water whereas the
unwanted crap dissolves in
water and not in toluene. Since water and toluene
separate into 2 layers the toluene layer
containing the cat free base is saved
and the water layer thrown out. The toluene could
probably be evaporated
leaving crystals of cat free base which could probably be smoked but I
haven’t
heard of anyone smoking it nor have I heard of its effects on the human body.
The cat free base is converted to cat salt using dilute hydrochloric acid or
anhydrous HCL
gas. Cat salt is soluble in water and not in toluene, just the
opposite of the free base.
Using HCL gas the salt produced has no water layer
to dissolve in so it crystalizes out. Using
dilute HCL the salt leaves the
toluene layer as before but has a water layer (the water
diluting the HCL) to
dissolve in. This water layer is saved and the water evaporated, leaving
methcathinone-HCL.
_____________________________________________________________________________
Sources of
items:
~~~~~~~~~~~~~~~~
EPHEDRINE pills- Sadly, GNC (General Nutrition Centers)
corporate stores no
longer carry "Revive" (ephedrine-HCL pills). The franchise
stores are selling
what they have left in stock and will no longer carry the straight
ephedrine
pills. They will only carry the crap with guaifenesin added. It looks like
mail order will be the only possible source. Anybody ordering through the
mail will probably
have their name and address recorded and possibly sent to
the DEA.
TOLUENE-
Available at most hardware stores. One brand is called "Toluol" from
Parks. TOLUENE
is also called METHYLBENZENE.
LYE- Available at most hardware stores. Even Safeway has
it. One brand is
"Red Devil Lye" which is used to unclog grease clogs in drains.
CONCENTRATED HCL and CONCENTRATED SULFURIC ACID are pretty cheap. When bought
in
2-liter bottles (reagent grade) they’re about $20 each. HCl, also called
MURIATIC ACID, is
available as a concrete cleaner in most lumber yards. Also
used to adjust pH in swimming
pools. H2SO4, aka Battery Electrolyte,
obtainable in quart to 5-gallon size containers from
automotive supply
houses. This is a dilute acid which must be concentrated by pouring into
large pyrex containers and boiling the water off for many minutes. It has
reached the
point of 98% concentration when the liquid stops boiling and
starts fuming off with the
release of white clouds of gas (SO3, SULFUR
TRIOXIDE). Bottle while still hot as conc. H2SO4
is hygroscopic (it sucks
water out of the air and becomes dilute again). DO NOT BREATHE SO3
GAS! It
eats out your lungs, just as HCl GAS does.
CHROMIUM TRIOXIDE (CHROMIC
OXIDE) (CrO3)- Very common oxidizer. Comes in
powder form. Less than $20 for 100 grams. Since
it can be recycled, someone
would never have to purchase large quantities of it. Enough to use
as a
reagent and a supply to supplement the losses incured during use would be
enough.
Glass tubing- About $2 per tube (1/4 inch) at chemistry supply outlets. Bent
Glass tubing also
used in salt water aquariums. Also for neon signs. Many
sources for glass tubing from
veterinary to dairy, from industrial to hobby.
Easy to find if you know how to look.
_____________________________________________________________________________
CREDITS
~~~~~~~
"Secrets of Methamphetamine Manufacture" by Uncle Fester was
used as a
reference. Information about it is in the beginning of this article.
Technical assistance was provided by Steve J. Quest.
_____________________________________________________________________________
=============================================================================
Newsgroups: alt.drugs
From: andersom@spot.Colorado.EDU (Marc Anderson)
Subject: Re: Info
on methcathinone
Message-ID: <1993Jul1.222440.8062@ucsu.Colorado.EDU>
Date: Thu, 1
Jul 1993 22:24:40 GMT
—–BEGIN PGP SIGNED MESSAGE—–
[some text
deleted -cak]
medline only has two entries for ‘methcathinone’, both of which
follow:
- -marc
andersom@spot.colorado.edu
- ———- cut here
———
AU - Glennon RA
AU - Yousif M
AU - Naiman N
AU - Kalix P
AB - The purpose of the
present investigation was to examine the effect of
N-monomethylation of phenylisopropylamine
derivatives on amphetamine-
like activity. In tests of stimulus generalization using rats
trained
to discriminate 1.0 mg/kg of (+)-amphetamine from saline, the N-
monomethyl
derivatives of 1-(X-phenyl)-2-aminopropane, where X = 2,4-
dimethoxy (2,4-DMA), 3,4-dimethoxy
(3,4-DMA), 2,4,5-trimethoxy
(2,4,5,-TMA), and 2-methoxy-4,5-methylenedioxy (MMDA-2), did
not
produce amphetamine-appropriate responding at the doses evaluated.
However, the
N-monomethyl derivative of cathinone (i.e.,
methcathinone), like cathinone, resulted in
stimulus generalization.
Further studies with this agent revealed that (a) in the
amphetamine-
trained animals, methcathinone (ED50 = 0.37 mg/kg) is more potent
than
racemic cathinone or racemic amphetamine (ED50 = 0.71 mg/kg in
both cases), (b) methcathinone
is capable of inducing release of
radioactivity from [3H]dopamine-prelabeled tissue of rat
caudate
nucleus in a manner similar to that observed with cathinone,
amphetamine, and
methamphetamine, and (c) methcathinone is more
potent than cathinone as a locomotor stimulant
in mice as determined
by their effect on spontaneous activity. The results of the present
prototypic psychostimulants
amphetamine/methamphetamine and
cathinone/methcathinone, and lend further support to the
concept that
amphetamine and cathinone correspond in their pharmacological
effects.
DP - 1987 Mar
TA - Pharmacol
Biochem Behav
PG - 547-51
IP - 3
VI - 26
IS - 0091-3057
UI -
87204443
AU - Goldstone MS
TI - ‘Cat’: methcathinone–a new drug of abuse
[letter]
AB - [No Abstract Available]
SO - JAMA 1993 May 19;269(19):2508
DP - 1993
May 19
TA - JAMA
PG - 2508
IP - 19
VI - 269
IS - 0098-7484
UI -
93253905
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