i doubt mixing the chemicals will result in a "chemical reaction" inside of you, but you should be cautious because mixing a stimulant with two depressants of high potency will definitely mess you up mentally, whether it is for a high or brain damage. its not good for the heart either because the mdma causes the heart to pump faster and the oxy and codeine makes your heart pump slower. a good comparison, though on different proportions, would be mixing red bull with vodka....its not good cardiovascularly.
i doubt the combo of all three will react with each other in a negative way, but be mindful in terms of the amount you take (or sell to people) and how unheatlhy it may be for you. best of luck though and let us know what it is like if you happen to create and try it
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"Skills are cheap. Chemistry is expensive." -Mal Pancoast
"Power grows out of the barrel of a gun." -Mao Zedong
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